| 產(chǎn)品編號 | bs-0396R |
| 英文名稱 | VCAM1 Rabbit pAb |
| 中文名稱 | 血管內(nèi)皮細(xì)胞粘附分子（CD106）抗體 |
| 別 名 | VCAM1; CD 106; CD106; CD106 Antigen; DKFZp779G2333; INCAM 100; L1CAM; MGC99561; Vascular Cell Adhesion Molecule 1; Vascular cell adhesion protein 1; VCAM 1; VCAM-1; INCAM-100; V-CAM 1; VCAM1_HUMAN. |
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Specific References (16) | bs-0396R has been referenced in 16 publications.
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| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 細(xì)胞粘附分子 內(nèi)皮細(xì)胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Mouse |
| 產(chǎn)品應(yīng)用 | WB=1:200-1000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 81 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant Mouse VCAM 1 protein <Extracellular> |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
VCAM1 is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells. Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. Subunit: Binds to ECMV-D capsid proteins and acts as a receptor for this virus. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow. Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Database links: Entrez Gene: 7412 Human Entrez Gene: 22329 Mouse GenBank: NP_001069.1 Human GenBank: NP_001186763.1 Human Omim: 192225 Human SwissProt: P19320 Human SwissProt: P29533 Mouse
VCAM 1（CD106）是一種膜相關(guān)蛋白，分布于血管內(nèi)皮及其周圍的淋巴細(xì)胞、單核細(xì)胞、嗜酸性粒細(xì)胞和中性粒細(xì)胞。Anti-VCAM-1主要用于各種組織中血管內(nèi)皮的檢測。 |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Mouse Kidney tissue lysates
Lane 2: Mouse Spleen tissue lysates
Lane 3: Mouse Cerebrum tissue lysates
Primary: Anti-VCAM1 (bs-0396R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 81 kDa
Observed band size: 100 kDa
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