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HDAC1 Rabbit pAb, Nuclear Loading Control (bs-24447R)  
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50ul/1180.00元
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產(chǎn)品編號 bs-24447R
英文名稱 HDAC1 Rabbit pAb, Nuclear Loading Control
中文名稱 組蛋白去乙?;?(核內(nèi)參)抗體
別    名 DKFZp686H12203; GON 10; HD 1; HD1; HDAC 1; hdac1: histone deacetylase 1; Histone deacetylase 1(HD1); Histone deacetylase 1; RPD3(reduced potassium dependency yeast homolog) like 1; RPD3(reduced potassium dependency); RPD3; RPD3L1; HDAC1_HUMAN.  
產(chǎn)品類型 內(nèi)參抗體 
研究領(lǐng)域 腫瘤  心血管  發(fā)育生物學(xué)  干細胞  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應(yīng) Human (predicted: Mouse,Rat)
產(chǎn)品應(yīng)用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 53 kDa
檢測分子量
細胞定位 細胞核 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HDAC1: 1-100/480 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產(chǎn)品介紹 Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.

Subcellular Location:
Nucleus.

Tissue Specificity:
Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.

Post-translational modifications:
Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. Phosphorylated by CDK5.
Ubiquitinated by CHFR, leading to its degradation by the proteasome. Ubiquitinated by KCTD11, leading to proteasomal degradation.

Similarity:
Belongs to the histone deacetylase family. HD type 1 subfamily.

SWISS:
Q13547

Gene ID:
3065

Database links:

Entrez Gene: 3065 Human

Entrez Gene: 433759 Mouse

Entrez Gene: 297893 Rat

Entrez Gene: 404126 Cow

Omim: 601241 Human

SwissProt: Q32PJ8 Cow

SwissProt: Q13547 Human

SwissProt: O09106 Mouse

SwissProt: Q4QQW4 Rat

Unigene: 88556 Human

Unigene: 202504 Mouse

Unigene: 391033 Mouse

Unigene: 1863 Rat



組蛋白去乙?;?HDACs)是一組在細胞染色質(zhì)水平、通過誘導(dǎo)組蛋白去乙?;瘉碚{(diào)控包括染色質(zhì)重組、轉(zhuǎn)錄活化或抑制、細胞周期、細胞分化及細胞凋亡等一系列生物學(xué)效應(yīng)的酶,特別是與細胞活化后的基因轉(zhuǎn)錄表達調(diào)控有關(guān)。
產(chǎn)品圖片
Sample: Lane 1: Hela (Human) Cell Lysate at 30 ug Lane 2: Molt-4 (Human) Cell Lysate at 30 ug Lane 3: U251 (Human) Cell Lysate at 30 ug Lane 4: U937 (Human) Cell Lysate at 30 ug Primary: Anti-HDAC1 (bs-24447R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60-65 kD Observed band size: 60 kD
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